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. 2017 Feb 10;24(4):717–730. doi: 10.1038/cdd.2017.5

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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PKC–DLX3-dependent control of cutaneous homeostasis. Schematic working model of PKC–DLX3 signaling in keratinocytes displaying that, in response to differentiation or pro-inflammatory stimuli, such as calcium or TPA, DLX3 regulates PKC-dependent gene expression signature associated with barrier defects, inflammatory mediator release, antimicrobial peptides and cell cycle. Independently of PKC, DLX3 is implicated in the transcriptional control of other pathways, such as negative regulation of transcription, Wnt signaling, phosphatase activity and cell adhesion. Globally this signaling is determinant for the maintenance of the cutaneous homeostasis