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. Author manuscript; available in PMC: 2018 Mar 28.
Published in final edited form as: J Control Release. 2016 Oct 11;250:77–85. doi: 10.1016/j.jconrel.2016.10.011

Figure 5.

Figure 5

Mean DOX concentrations estimates (± SD) at 1 and 24 hours after FUS for the sonicated and non-sonicated tumors and for the regions in the normal brain. At both times, the concentrations in the sonicated areas were significantly larger (P<0.01) than the non-sonicated controls. The concentration in the non-sonicated tumors was significantly less at 24 hours than at 1 hour, and little DOX was found in the non-sonicated brain regions at either time point. In contrast, there was no significant difference in DOX concentrations at 1 and 24 hours for both the sonicated tumors and the sonicated normal brain regions, suggesting that the sonications enhanced drug retention.