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. Author manuscript; available in PMC: 2018 Mar 10.
Published in final edited form as: Eur J Med Chem. 2017 Jan 30;128:168–179. doi: 10.1016/j.ejmech.2017.01.041

Figure 1.

Figure 1

Variants of the HPD chemotype. (a) HPD subtypes 1—3 have been reported to inhibit RT and/or INST of HIV-1; (b) replacement of the C-6 phenyl ring of subtype 1 led to subtype 4 with substantially different biological activity profiles.