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. Author manuscript; available in PMC: 2018 Mar 10.
Published in final edited form as: Eur J Med Chem. 2017 Jan 30;128:168–179. doi: 10.1016/j.ejmech.2017.01.041

Table 2.

Biochemical and antiviral assay results of 3-deoxy precursor 11

Compd Structure RT IC50 a (μM) MAGI Antiviral
RNH Pol EC50b (μM) CC50c (μM)
11a graphic file with name nihms850275t14.jpg >10 0.085 ± 0.034 0.0052 ± 0.0024 23 ± 0.74
11b graphic file with name nihms850275t15.jpg >10 0.30 ± 0.034 0.0072 ± 0.0029 31 ± 1.4
11c graphic file with name nihms850275t16.jpg >10 0.22 ± 0.12 0.0062 ± 0.00020 >50
11d graphic file with name nihms850275t17.jpg >10 0.48 ± 0.089 0.0075 ± 0.0010 42 ± 2.7
11e graphic file with name nihms850275t18.jpg >10 1.5 ± 0.50 0.048 ± 0.029 32 ± 0.67
11f graphic file with name nihms850275t19.jpg >10 0.82 ± 0.014 0.014 ± 0.0058 29 ± 0.78
11g graphic file with name nihms850275t20.jpg >10 0.81 ± 0.59 0.039 ± 0.012 28 ± 0.81
11h graphic file with name nihms850275t21.jpg >10 0.36 ± 0.17 0.011 ± 0.0035 30 ± 1.30
11i graphic file with name nihms850275t22.jpg >10 6.8 ± 2.0 0.065 ± 0.017 >100
11j graphic file with name nihms850275t23.jpg >10 10 0.83 ± 0.020 38 ± 3.2
11k graphic file with name nihms850275t24.jpg >10 10 0.21 ± 0.062 65 ± 3.5
11l graphic file with name nihms850275t25.jpg >10 10 0.80 ± 0.11 >100
11m graphic file with name nihms850275t26.jpg >10 >10 5.3 ± 0.43 56 ± 0.83
14 -- >10 0.42 ± 0.24 0.011 ± 0.00010 58 ± 2.4
a

Concentration of compound inhibiting the target enzyme by 50%.

b

Concentration of compound inhibiting virus replication by 50%.

c

Concentration of compound resulting in 50% cell death. All assay results expressed as mean ± standard deviation from at least two independent experiments.