Gender comparison of the absolute serum creatine kinase (CK) activity pre- and post downhill running expressed as mean ± SD (a); and the magnitude of CK response post downhill running expressed as the average change relative to pre-exercise and 95% confidence interval (b). ##, ### and #### denotes a significant difference relative to pre-exercise (–20 min) within a group, p < 0.01, p < 0.001 and p < 0.0001, respectively. *, ** and *** denotes a significant difference between groups at that time point, p < 0.05, p < 0.01 and p < 0.001, respectively. ψ denotes a trend for difference between groups at this time point, p = 0.08.