Figure 2.

Levels of α-tocopheryl nicotinate in the heart of healthy control rats and rats with heart failure. Pulmonary arterial hypertension-induced right-sided heart failure was generated by administering ovalbumin and SU5416 to Sprague-Dawley rats [16]. Homogenates of right-heart ventricular tissues were injected into a reverse-phase column of an Acquity ultra-performance liquid chromatography (UPLC) system. Mass spectrometry (MS) was performed using a quadrupole-time-of-flight mass spectrometer. The box-and-whisker plot represents the levels of the metabolite corresponding to α-tocopheryl nicotinate (m/z 536.4077) in arbitrary units (a.u.). * denotes significant difference between each other at p < 0.05.