Figure 1. Enrichment of essential genes in different protein-protein interaction datasets of E. coli.

(A) Overlaps between sets of proteins that are involved in binary-Y2H, co-complex and literature curated binary protein-protein interaction data sets in E. coli, including the number of essential proteins that are involved in interactions (brackets). (B) Enrichment of essential bacterial proteins as a function of their number of interactions in E. coli and S. cerevisiae. Notably, we observed that binary-Y2H interactions failed to show an ascending trend compared to literature curated binary and co-complex interactions in both organisms.