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. 2017 Apr 7;7:46322. doi: 10.1038/srep46322

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Wild-type mice were administered alendronate for two weeks. Then, infectious osteomyelitis was established by Streptococcus aureus infection of left femurs. The TNFα inhibitor etanercept (eta) or ISO type control (ISO) was subcutaneously injected one week before surgery and then subsequently twice a week. Seven days after surgery, cortical bone sections of left femurs were prepared and stained with HE (a), and the proportion of empty versus whole lacunae was calculated (b). Scale bars = 100 (upper) or 10 μm (lower panels). Data shows the mean percentage (%) of empty versus whole lacunae ± SD (n = 4, *P < 0.05). Representative data of at least two independent experiments are shown.