Table 1. Neutralization magnitude distribution between different sample groups based on neutralization breadth.Note: GMTs are shown. ID50 values < 20 (lowest sample dilution tested) were assigned a value of 10. Bold type indicates subtype-specific values.*indicates Tier 3 virus, †indicates Tier 1B virus.
| Control | Tier 1 A (n = 2) | CRF07_BC (n = 10) |
Subtype A (n = 4) |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group based on NAb breadth | SVA-MLV | MW965.26 | SF162.LS | CH064. 20 | CH070.1* | CH091.9 | CH110.2 | CH114.8* | CH115. 12* | CH117.4 | CH119. 10 | CH120.6* | CH181. 12 | CRF- specific | Q461.e2 | Q769.d22 | Q259.d2. 17 | Q842. d12 | Subtype- specific |
| BCN (n = 18) | 10 | 56334 | 4901 | 184.3 | 160.3 | 470.5 | 518.0 | 361.2 | 250.5 | 503.1 | 520.4 | 89.3 | 630.2 | 314.9 | 39.1 | 91.7 | 170.2 | 156.5 | 98.8 |
| M-BCN (n = 34) | 10 | 42668 | 5166 | 64.6 | 38.9 | 241.1 | 289.0 | 140.0 | 111.3 | 142.1 | 340.2 | 26.1 | 93.1 | 112.3 | 13.0 | 33.1 | 32.2 | 24.9 | 24.2 |
| Non-BCN(n = 46) | 10 | 23864 | 2903 | 22.4 | 20.1 | 84.5 | 40.4 | 28.2 | 83.4 | 34.8 | 191.8 | 15.7 | 31.1 | 40.5 | 10.0 | 10.7 | 12.3 | 10.0 | 10.7 |
| Overall (n = 98) | 10 | 34183 | 3903 | 47.6 | 37.0 | 166.7 | 127.8 | 78.5 | 112.8 | 92.6 | 281.0 | 25.7 | 79.0 | 84.1 | 14.1 | 23.5 | 27.8 | 22.8 | 21.4 |
|
Subtype C (n = 5) |
Subtype B (n = 7) |
CRF01_AE (n = 4) |
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| Du422.1 | ZM249M.PL1 | ZM55F.PB28a | ZM109F.PB4† | CAP45.2.00.G3 | Subtype-specific | QH0692.42 | SC422661.8 | PVO.4* | RHPA4259.7 | REJO4541.67 | TRJO4551.58* | CAAN5342.A2 | Subtype-specific | BM2149 | BM2249 | BM2316 | BM2498 | CRF-specific | |
| BCN(n = 18) | 250.3 | 242.2 | 142.3 | 243.7 | 206.4 | 212.6 | 25.4 | 20.2 | 87.4 | 149.1 | 169.7 | 171.5 | 46.8 | 71.0 | 131.1 | 21.9 | 24.7 | 24.2 | 36.2 |
| M-BCN(n = 34) | 116.5 | 115.1 | 44.6 | 179.2 | 132.7 | 107.3 | 11.9 | 11.8 | 31.1 | 53.6 | 83.9 | 56.4 | 13.1 | 28.3 | 28.4 | 12.2 | 13.2 | 14.0 | 15.9 |
| Non-BCN(n = 46) | 22.9 | 22.7 | 11.9 | 70.2 | 23.7 | 25.3 | 10.0 | 10.0 | 14.6 | 14.4 | 22.0 | 17.6 | 10.9 | 13.7 | 12.3 | 10.0 | 10.0 | 10.0 | 10.5 |
| Overall (n = 98) | 62.5 | 61.6 | 29.6 | 122.1 | 64.2 | 61.7 | 12.6 | 12.1 | 26.3 | 34.9 | 51.0 | 40.1 | 15.2 | 23.8 | 25.3 | 12.4 | 13.0 | 13.2 | 15.2 |