Table 3. Gene set enrichment analysis of severe obese children associated CpGs.
| Gene Set Name | Genes in Gene Set | Description of the Set | Genes in Overlap (n) | Genes in Overlap (Name) | p.value | FDR q.value |
|---|---|---|---|---|---|---|
| TUMOR ZONE PERIPHERA VS CENTRAL DN | 634 | Down-regulated genes in peripheral zone of human pancreatic cancer growing in the pancreas of nude mice compared to that of the tumor from the central zone | 8 | GMDS FAM59A COL6A1 P4HB NXPH4 RAB3D FAT2 KIAA1530 | 6.22e-6 | 1.78e-2 |
| ENDOCRINE THERAPY RESISTANCE 3 | 720 | The ‘group 3 set’ of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 | 8 | GMDS FAM59A FBN2 SLC7A14 TMEM45B ATP2C2 ACVR2A STARD4 | 1.56e-5 | 1.78e-2 |
| ADULT TISSUE STEM MODULE | 721 | The ‘adult tissue stem’ module: genes coordinately up-regulated in a compendium of adult tissue stem cells | 8 | COL6A1 ID4 COL1A1 HLX FLOT1 DIP2C CBFA2T3 EPHB4 | 1.57e-5 | 1.78e-2 |
| IRS1 TARGETS UP | 113 | Up-regulated in brown preadipocytes with IRS1 knockout vs wild type controls; the knockouts have severe defects in adipocyte differentiation | 4 | FBN2 CYBA WNT10A HSPA4 | 2.97e-5 | 2.34e-2 |
| LIVER CANCER SUBCLASS S1 | 237 | Genes from ‘subtype S1′ signature of hepatocellular carcinoma (HCC): aberrant activation of the WNT signaling pathway | 5 | COL6A1 CYBA ITPR3 TAX1BP3 RPA2 | 3.45e-5 | 2.34e-2 |
| COLON CANCER UP | 871 | Up-regulated genes in colon carcinoma tumors compared to the matched normal mucosa samples | 8 | GMDS CYBA ITPR3 COX6B1 THOP1 SH3GL1 DLGAP4 SHFM1 | 5.98e-5 | 3.39e-2 |
This table displays gene pathways overrepresented among the 151 differentially methylated CpGs (FDR q.value < 0.05).