Figure 4. Time-series OncoScore plot spanning from 1975 to 2016.
(a) Time-series plot involving a set of manually defined cancer (TP53, KRAS, NRAS, HRAS, ASXL1, IDH1, IDH2, TET2 and SETBP1) and housekeeping genes (GAPDH and GUSB). The grey boxes highlight two major scientific breakthroughs occurred during this time span. (b) Time-series plot of 10 genes randomly selected from the CGC (ARID1A, HMGA2, KIF5B, NUP214, RBM15; dashed lines) and nCan (ALMS1, DCAF17, GPD1L, WFS1, RBM10; continuous lines) dataset.