Table 1. Prospective studies of hypertension and endometrial cancer.
| First author, publication year, country | Number of participants, age, number of cases | Study period | Assessment of hypertension | Cut-off for hypertension | Exposure | Comparison | Relative risk (95% confidence interval) | Adjustment for confounders |
|---|---|---|---|---|---|---|---|---|
| Mack T et al., 1976, USA | Nested case-control study: 63 cases 252 controls | 1971–1975, ~4 years follow-up | Self-reported | Not available | Hypertension | Yes vs. no | 1.50 (0.85–2.64) | Age, marital status, community |
| Tulinius H et al., 1997, Iceland | 11580 women, mean age 50.5 years: 98 cases | 1968–1995, ~15.1 years follow-up | Measured | Not available | Hypertension | Yes vs. no | 1.9 (1.2–2.9) | Age |
| Folsom AR et al., 2003, USA | 23335 women, age 55–69 years: 415 cases | 1986–2000, 15.7 years follow-up | Self-reported | Not available | Hypertension | Yes vs. no | 1.53 (1.26–1.86) | Age |
| Furberg AS et al., 2003, Norway | 24460 women, age 20–49 years: 130 cases | 1974–1981–1996, 15.7 years follow-up | Measured (mercury sphygmo-manometer) | ≥140/≥90 mmHg | Hypertension | Consistently normotensive | 1.00 | Age, geographical region, height, BMI, recreational and occupational activity, smoking, parity |
| Hypertensive in one survey | 1.11 (0.70–1.77) | |||||||
| Consistently hypertensive | 1.24 (0.69–2.25) | |||||||
| Ollberding NJ et al., 2011, USA | 46027 postm. Women, age 45–75 years: 489 cases | 1993/1996–2007, 13.6 years follow-up | Self-reported | Not available | Hypertension | Yes vs. no | 1.24 (1.03–1.50) | Age, race/ethnicity, age at cohort entry, total calories, BMI, age at menarche, age at menopause, parity, duration of OC use, HRT use, smoking status, diabetes |
| Sponholtz TR et al., 2016, USA | 47577 women, age 21–69 years: 274 cases | 1995–2013, 14 years follow-up | Self-reported | Not available | Hypertension | Yes vs. no | 1.02 (0.78–1.33) | Age, study period, age at menarche, parity, menopausal status, OC use, estrogen-only hormone use, estrogen plus progestin hormone use, smoking status, BMI, vigorous physical activity, statin use, metformin use |
BMI = body mass index, OC use = oral contraceptive use, HRT use = hormone replacement therapy use.