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. 2017 Apr 7;7:45740. doi: 10.1038/srep45740

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Animals were stimulated with hydroxyproline (HPL) and ethylene glycol (ETG) during 30 (30D) or 60 (60D) days increased oxalate excretion (A) and increased urinary crystals number (Neubauer camera count) (B). Impaired renal function has been demonstrated through increased serum creatinine (C), decreased of creatinine clearance (D), and increased serum urea (E). Control values represent the average of the data for the control group. Data are presented as means ± standard errors. N = 5 for each group. (*) Indicates significant differences compared with the control group at p < 0.05.