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. 2015 Mar;15(3):245–252. doi: 10.2174/1566524015666150330144018

Fig. (2).

Fig. (2)

Effects of training and MPH on avoidance responding. (A) The sensitivity to footshock, expressed as response rate, was comparable in DAT+/+, DAT+/-, and DAT-/- mice (n = 17-23 per group). (B) Training alone was effective in DAT+/+ and DAT+/- mice but not in DAT-/- mice. Methylphenidate had beneficial effects on acquisition in this task in DAT-/- mice. The reduction of avoidance responding on day 6 in DAT+/+ and DAT+/- mice was transient and recovered by training. &P < 0.05, vs DAT+/+ mice; ***P < 0.001, vs day 5 (paired t-test); #P < 0.05, vs DAT+/+ mice; ###P < 0.001, vs DAT+/- mice (Scheffe’s test). The data are expressed as mean ± SEM.