Table 3.

Affinities of compounds for recombinant NMDA receptors [116, 117].

Agonist and co-agonist	GluN2A	GluN2B	GluN2C	GluN2D	GluN3A	GluN3B
EC50 (µM)
Glutamate	7.7	2.3	1	0.39
Glycine	1.2	0.38	0.32	0.12	57	95
Competitive antagonists	GluN2A	GluN2B	GluN2C	GluN2D	GluN3A	GluN3B
Ki (µM)
(R)-AP5	0.28	0.46	1.6	3.7
UBP141	14	19	4.2	2.8
Channel blockers	GluN2A	GluN2B	GluN2C	GluN2D	GluN3A	GluN3B
IC50 (µM)
(+)MK801	0.015	0.0099	0.024	0.038
Ketamine	5.4	5.1	1.2	2.9
Phencyclidine	0.82	0.16	0.16	0.22
Noncompetitive antagonists	GluN2A	GluN2B	GluN2C	GluN2D	GluN3A	GluN3B
IC50 (µM)
Ifenprodil	39	0.15	29	76
Ro25-6981	52	0.009
Allosteric potentiators	GluN2A	GluN2B	GluN2C	GluN2D	GluN3A	GluN3B
EC50 (µM)
CIQ	NE	NE	2.8	3.0

NE, no detectable effect.