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. 2017 Feb 6;6(3):e1287247. doi: 10.1080/2162402X.2017.1287247

Figure 1.

Figure 1.

PyMT/Il1r1−/− mice have an earlier tumor onset and increased metastasis compared with PyMT mice. (A) Kaplan–Meier tumor-free survival curves of PyMT (median = 99 d) or PyMT/Il1r1−/− mice (median = 72.5) (n = 10–20 per genotype, Mantel–Cox p < 0.0001). (B) Kaplan–Meier survival curves of PyMT (median = 170 d) or PyMT/Il1r1−/− mice (median = 140.5) (n = 20–30 per genotype, Mantel–Cox p < 0.0001). (C) Number of mammary gland with tumors at clinical end point (n = 15–20, Student's t-test p < 0.001). (D–F) Primary tumor burden (D), percentage of mice bearing metastasis (E) and average number of lung lesions per metastasis-bearing animals (F) at 5 mo of age of PyMT or PyMT/Il1r1−/− mice (n = 7–19 mice per genotype). Each symbol represents a mouse; the line represents the mean. (G-I) Primary tumor burden (G), percentage of mice bearing metastasis (H) and average number of lung lesions per metastasis-bearing animals (I) at clinical end point of PyMT or PyMT/Il1r1−/− mice (n = 16–17 mice per genotype, Student's t-test p < 0.01). Each symbol represents a mouse; the line represents the mean.