Figure 4.

Il-1r1 ablation does not affect the proportions of immune infiltrates in the mammary fat pad during early or late tumorigenesis. (A) Flow cytometric analysis of immune infiltrates as a percent of total CD45⁺ cells in mammary fat pad of PyMT or PyMT/Il1r1^−/− mice at 6 and 10 weeks of age (n = 7–8 mice per genotype, Student's t-test). (B) Flow cytometric analysis of intra-tumoral immune infiltrate populations as a percent of total CD45⁺ cells in mammary carcinomas of PyMT or PyMT/Il1r1^−/− mice when tumors reached a volume of 1 cm³ (n = 5 mice per genotype, Student's t-test).