Table 1.

Mitochondrial function in WT and 5XFAD mice fed normal or Nutra II containing chow.

	WT	5XFAD	5XFAD + Nutra II
ATP	1.00 ± 0.32	1.20 ± 0.20	1.39 ± 0.37
ROS	1.00 ± 0.36	1.23 ± 0.53	1.02 ± 0.35
State III	1.00 ± 0.12	1.33 ± 0.11	1.34 ± 0.34
State IV	1.00 ± 0.44	1.49 ± 0.49	2.01 ± 1.16
State V	1.00 ± 0.20	1.23 ± 0.32	1.64 ± 0.72
State III/IV	1.00 ± 0.12	0.89 ± 0.07	0.55 ± 0.19*†
State V/IV	1.00 ± 0.19	0.82 ± 0.21	0.63 ± 0.13*
Pol	5.20 ± 1.34	19.63 ± 7.66*	12.24 ± 6.64
Depol	1.00 ± 0.18	1.76 ± 0.46*	1.32 ± 0.44
Pol/Depol	1.00 ± 0.20	2.58 ± 0.55*	2.05 ± 0.88

ATP equals adenosine triphosphate, ROS equals reactive oxygen species, States III, IV and V equal respiratory states and Pol and Depol equals mitochondrial polarization and depolarization, respectively. The data was analyzed in two groups with different values for control WT mice between groups, particularly for RCR. Since the relative values were similar between groups after normalization to the WT mice (controls), the data were combined after normalization to the corresponding WT mice, except for Pol which was normalized to mean WT Depol value. RCR values for the WT mice (State III/IV and V/IV) were 16.43 ± 1.51 and 16.43 ± 2.43 for Group 1 and 4.84 ± 0.40 and 3.94 ± 0.53 for Group 2, respectively. RCR values in untreated 5XFAD mice were similar to WT mice, but in the Nutra II treated 5XFAD mice RCR values decreased to 6.50 ± 0.72 and 9.18 ± 1.31 for Group 1 and 3.45 ± 0.28 and 2.72 ± 0.15 for Group 2. Asterisk indicates P < 0.05 compared with WT. Dagger indicates P < 0.05 compared with 5XFAD untreated (Mean ± SD).