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Time Sequence of Biomarkers
The change in biomarkers appears to have the following sequence [3]:
| Sequence Order | Biomarker |
|---|---|
| 1 | An increase in CSF tau (although perhaps not reaching detection threshold until later) |
| 2 | A decrease in CSF Aβ as it accumulates in the brain |
| 3 | An increase in amyloid deposition using PET |
| 4 | Brain atrophy measured with MRI fMRI, and FDG PET |
| 5 | Cognitive impairment |
| 6 | Decreased clinical functioning and activities of daily living |
