Figure 3.

Overexpression of miR-205-5p reduced the cell invasion and migration ability through targeting VEGF in HKF. (a) Representative images of transwell assays, transfection of miR-205-5p mimics reduced the invasion and migration ability of HKF. (b) Representative images of cell cycle distribution as detected by flow cytometry, transfection of miR-205-5p mimics had no impact on the cell cycle distribution in HKF. (c) VEGF is a target of miR-205-5p. Sequence alignment of miR-205-5p and 3′-UTR of VEGF using TargetScan. (d) Luciferase activity in the VEGF-3′UTR-WT group was significantly decreased after miR-205-5p mimics transfection. ***P < 0.01. (A color version of this figure is available in the online journal.)