Table 3.
The comparison of iron overload, liver fibrosis and liver function in HSS and N-HSS (median, range)
| NTDT |
TM |
|||||
|---|---|---|---|---|---|---|
| HSS (n = 83) | N-HSS (n = 22) | p value | HSS (n = 65) | N-HSS (n = 74) | p value | |
| SF | 1283 (188–19,704) | 601 (36–1590) | p < 0.05 | 4538 (559–12,500) | 4305 (121–14,724) | p > 0.05 |
| LIC | 11.4 (0.8–43.0) | 5.8 (0.6–20.7) | p < 0.05 | 41.2 (8.4–43.0) | 42.4 (21.1–43.0) | p > 0.05 |
| C IV | 60 (9–25) | 63 (18–138) | p > 0.05 | 74 (52–126) | 73 (56–157) | p > 0.05 |
| PIIINP | 1.3 (0.0–53.4) | 0.3 (0.0–8.7) | p < 0.05 | 3.3 (0.0–41.6) | 2.9 (0.0–94.7) | p > 0.05 |
| HA | 25 (0–679) | 11 (0–137) | p < 0.05 | 64 (10–258) | 67 (8–864) | p > 0.05 |
| ALT | 19 (5–120) | 15 (9–58) | p > 0.05 | 42 (14–282) | 37 (8–232) | p > 0.05 |
| AST | 28 (11–119) | 26 (12–74) | p > 0.05 | 42 (18–177) | 42 (17–175) | p > 0.05 |
NTDT: non-transfusion-dependent thalassemia; TM: thalassemia major; SF: ferritin, ng/ml; LIC: liver iron overload, mg Fe/g dw; HA: hyaluronic acid, ng/ml; PIIINP: precollagen type III, ng/ml; C IV: collagen type IV, ng/ml; HSS: patients with history of hepatomegaly, splenomegaly or splenectomized; N-HSS: patients who without history of hepatomegaly, splenomegaly or splenectomized; ALT: alanine aminotransferase; AST: aspartate aminotransferase.