Figure 4.

Knockdown of Smc1β results in the generation of aneuploidy in mouse eggs. (A) Representative images of euploid and aneuploid MII eggs. Chromosome spread was performed to calculate the number of chromosomes. Chromosomes were counterstained with PtdIns. Scale bar, 5 μm. (B) The proportion of aneuploid eggs was recorded in control and Smc1β-MO oocytes. Data were presented as mean percentage (mean ± SEM) of at least 3 independent experiments. Asterisk denotes statistical difference at a p < 0.05 level of significance.