Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jan 5;16(6):522–532. doi: 10.1080/15384101.2016.1274471

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Taylor & Francis

PMC Copyright notice

Figure 4. — IRS1/2 mediate the effects of IGF1 on the differentiation of antler chondrocytes. (A) Effects of IRS1 siRNA on the expression of IRS1, IHH and IGF1. (B) Effects of IRS2 siRNA on the expression of IRS2, IHH and IGF1. (C) IRS1 expression in antler chondrocytes treated with rIGF1 for 1, 3, 6, 12 and 24 h. (D) IRS2 expression in antler chondrocytes treated with rIGF1 for 1, 3, 6, 12 and 24 h. (E) Expression of IRS1 and IRS2 after antler chondrocytes were treated with rIGF1, or rIGF1 and PQ401. (F) Effects of IGF1 overexpression on the expression of IRS1 and IRS2. (G) Effects of IGF1 siRNA on the expression of IRS1 and IRS2. (H) IRS1 mediated the effects of IGF1 on the expression of IHH. After transfection with IRS1 siRNA and addition of rIGF1, the expression of IHH was determined by real-time PCR. (I) IRS2 mediated the effects of IGF1 on the expression of IHH. siIRS1, IRS1 siRNA; siIRS2, IRS2 siRNA.