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. 2017 Jan 24;16(6):499–507. doi: 10.1080/15384101.2017.1282586

Figure 6.

Figure 6.

Genetic ablation of FASN in the mouse liver does not affect tumor development driven by c-Met/β-catenin co-expression. (A) Study design: Overexpression of c-Met/β-catenin promotes the development of multiple hepatocellular carcinomas both in FASNfl/fl mice with an intact FASN gene (n = 4) and in those where FASN was deleted by the Cre system (AlbCre;FASNfl/fl mice; n = 4). (B) c-Met/β-catenin induced HCC formation in wild-type and liver-specific FASN KO mice with the same latency and histology. (C) Survival curve of FASNfl/fl mice (n = 4) and liver-specific FASN KO mice (AlbCre;FASNfl/fl mice; n = 4) injected with c-Met/β-catenin, P = 0.35. Scale bar: 200µm for H&E and FASN, 100 µm for Ki-67. Abbreviations: FASN, fatty acid synthase; HE, hematoxylin and eosin staining.