Table 2.

Relative expression of genes related to glucose uptake and lipid metabolism in adipose tissue from IS and IR subjects at baseline and changes with weight gain

Gene	IS baseline* (n = 10)	IR baseline* (n = 10)	P baseline	IS ∆	IR ∆	P ∆
Glut4	1.1 ± 0.52	0.62 ± 0.41	0.02	−0.08 ± 0.33	0.47 ± 0.50‡	0.01
FABP4	1.08 ± 0.22	0.89 ± 0.28	0.08	−0.21 ± 0.21‡	0.13 + 0.41	0.04
PEPCK	1.00 ± 0.22	0.67 ± 0.24	0.003	−0.18 ± 0.24†	0.16 ± 0.37	0.01
ACC1	1.67 ± 1.1	1.13 ± 0.74	0.21	0.29 ± 0.99	0.49 ± 0.72	0.53
CD36	1.21 ± 0.40	1.08 ± 0.31	0.37	−0.03 ± 0.46	0.08 ± 0.52	0.52
FATP1	1.00 ± 0.17	0.85 ± 0.22	0.06	−0.14 ± 0.19†	0.10 ± 0.36	0.08
LPL	1.44 ± 0.55	1.22 ± 0.40	0.29	0.02 ± 0.61	0.23 ± 0.53	0.39
HSL	1.35 ± 0.37	1.02 ± 0.35	0.049	−0.19 ± 0.30	0.30 ± 0.56	0.03
ATGL	1.47 ± 0.32	1.07 ± 0.29	0.01	−0.30 ± 0.39†	0.17 ± 0.26	0.006

^*Baseline comparison adjusted for baseline %BF; change comparison adjusted for ∆%BF. Relative expression at peak weight was normalized to baseline expression for each gene and change calculated as the difference between peak weight and baseline relative expression;

^†Paired t test comparing peak weight to baseline P < 0.05;

^‡Paired t test comparing peak weight to baseline P < 0.01.