Figure 7.

The intraomental biologic scaffold supports the engraftment of allogeneic islets under systemic immunosuppression in diabetic rats. A fully MHC-mismatched allogeneic rat transplant combination in which diabetic female Lewis rat (RT1^l) (n = 4) received 3,000 IEQ WF rat islets (RT1^u) in the intraomental biologic scaffold under a protocol of clinically relevant immunosuppressive agents consisting of lymphodepletion induction with anti-lymphocyte serum (0.5 mL i.p. on day −3) and maintenance with mycophenolic acid (MPA) (20 mg/kg/day for days 0–14, then tapered by one-quarter of the dose every 2 days until day 20) and CTLA4Ig (10 mg/kg i.p. on days 0, 2, 4, 6, 8, and 10 and weekly thereafter; abatacept) (arrows). Nonfasting glycemic values for each animal during the follow-up are presented. Graft rejection was defined as return to hyperglycemic state. Each symbol represents an individual animal.