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. 2016 Feb 25;65(5):1350–1361. doi: 10.2337/db15-1525

Figure 8.

Figure 8

Intraomental allogeneic islet transplantation in a diabetic nonhuman primate. A diabetic cynomolgus monkey received 9,347 IEQ/kg allogeneic islets in the omentum under the cover of clinically relevant immunosuppression therapy. A: Exogenous insulin requirement (EIR) (IU/kg/day), FBG (mg/dL), and PBG. B: Fasting C-peptide (ng/mL) levels measured in the animal over the follow-up period. C–G: Histopathologic pattern of intraomental islet graft on day 49 posttransplant. C: Hematoxylin-eosin staining. D: Immunofluorescence microscopy for the evaluation of immunoreactivity for insulin (INS) (red), GCG (green), and nuclear dye (DAPI) (blue). E: Immunofluorescence for insulin (red) and CD3+ T cells (CD3) (cyan). F and G: Intrainsular neovasculogenesis. F: Immunofluorescence for insulin (red), vascular structure (SMA) (green), and DAPI (blue). G: Immunofluorescence microscopy for insulin (red), endothelial cells (vWF) (green), and DAPI (blue).