Table 1. Characteristics of allopurinol user and controls, propensity score matched 1:1.

Comorbidity	All, N=172,078
	Allopurinol user N= 86,039		Control (matched 1:1) N= 86,039
	N	%	N	%	P (fishers exact)
Age Mean (SD)	63(15.1)		63(15.1)		0.985
Range (Min, Max)	18-103		18-103
Sex Men	58,072	67	58,072	67	1.0
Women	27,967	33	27,967	33
PPS (mean)	191		161		<0.001
PPS difference (mean)	44.3		44.3		1.0
Distance (mean)	222		222		1.0
Charlson index (mean)	0.93		0.74		<0.001
Charlson comorbidity components
Myocardial infarction	5,504	6.4	4,289	5.0	<0.001
Heart failure	15,457	18	11,745	14	<0.001
Peripheral vascular disease	3,510	4.1	2,744	3.2	<0.001
Cerebrovascular disease	5,508	6.4	4,925	5.7	<0.001
Dementia	584	0.7	779	0.9	<0.001
Pulmonary disease	6,003	7.0	4,861	5.7	<0.001
Rheum/Collagen disorders	1,748	2,0	1,399	1.6	<0.001
Ulcer disease	2,806	3.3	2,288	2.7	<0.001
Mild liver disease	900	1.1	818	1.0	0.049
Diabetes without complications	5,134	6.0	4,038	4.7	<0.001
Diabetes with complications	1,929	2.2	1,342	1.6	<0.001
Paralysis	190	0.2	187	0.2	0.918
Renal failure	1,187	1.4	663	0.8	<0.001
Malignancy	2,599	3.0	2,221	2.6	<0.001
Severe liver dis	195	0.2	142	0.2	0.004
Metastatic cancer	86	0.1	114	0.1	0.056
AIDS or HIV	26	0.03	24	0.03	0.888
Fracture history
Spine	446	0.5	416	0.5	0.322
Humerus	1,313	1.5	1,088	1.3	<0.001
Forearm	3,119	3.6	2,657	3.1	<0.001
Hip	1,281	1.5	1,362	1.6	0.117
Major osteoporotic	5,565	6.5	4,885	5.7	<0.001
Any fracture	13,071	15	12,170	14	<0.001
Medications
Osteoporosis	1,358	1.6	1,058	1.2	<0.001
HRT	5,009	5.8	4,612	5.4	<0.001
Oral diabetes	5,331	6.2	4,197	4.9	<0.001
Insulin	2,025	2.4	1,711	2.0	<0.001
NSAID	50,765	59	46,020	54	<0.001
Prednisolone	5,137	6.0	4,120	4.8	<0.001
Lipid lowering	13,526	16	10,140	12	<0.001
Antihypertensive	31,147	36	25,403	30	<0.001