Table 3. Risk of osteoporotic fracture among Danish subjects taking allopurinol, using 1:1 matching.
Hip fracture | Major fracture | |||||
---|---|---|---|---|---|---|
Men | Women | All | Men | Women | All | |
Model 1 | 1.13 (1.03, 1.24) | 1.07 (0.99, 1.16) | 1.10 (1.03, 1.16) | 1.22 (1.16, 1.29) | 1.04 (0.99, 1.09) | 1.12 (1.08, 1.16) |
Model 2 | 1.09 (0.99, 1.20) | 1.03 (0.95, 1.12) | 1.05 (0.99, 1.12) | 1.20 (1.14, 1.27) | 1.00 (0.95, 1.05) | 1.08 (1.04, 1.13) |
Model 3 | 1.11(1.01, 1.23) | 1.05 (0.96, 1.14) | 1.10 (1.00, 1.14) | 1.21 (1.14, 1.29) | 1.00 (0.95, 1.06) | 1.09 (1.05, 1.14) |
Figures given are HRs, with 95% CIs
Model 1: allopurinol use
Model 2: allopurinol use, prior fracture, known comorbidity
Model 3: allopurinol use, prior fracture, known comorbidity, drug history