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. Author manuscript; available in PMC: 2017 Apr 7.
Published in final edited form as: Arch Osteoporos. 2015 Oct 19;10:36. doi: 10.1007/s11657-015-0241-4

Table 5. Risk of fracture according to allopurinol exposure.

Hip fracture P value Major fracture P value
Women
Lowest tertile, <82 mg/d      0.99(0.85-1.15) 0.87      0.95(0.86-1.04) 0.24
Mid tertile      0.95(0.83-1.08) 0.42      0.95(0.87-1.04) 0.24
Highest tertile, >164 mg/d      1.22(1.06-1.41) 0.007      1.13(1.03-1.24) 0.01
Men
Lowest tertile, <82 mg/d      0.99(0.81-1.21) 0.92      1.20(1.08-1.34) 0.001
Mid tertile      1.18(0.99-1.40) 0.06      1.16(1.05-1.29) 0.003
Highest tertile, >164 mg/d      1.15(0.98-1.35) 0.09      1.27(1.15-1.40) 0

Figures given are HRs, with 95% CIs, adjusted for prior fracture, known comorbidity, drug history.

Cumulative allopurinol dose filled in the first treatment year divided by number of days, censored at death or fracture.