Table 1.
Human histone deacetylase: classification, localization, and inhibitors. Reproduced, with permission, from (120).
| Class | Enzymes | Localization | Expression | Drugs |
|---|---|---|---|---|
| I | HDAC 1, 2, 3, and 8 | Nucleus | Ubiquitous | Vorinostat, trichostatin A, belinostat, panobinostat, romidepsin, etinostat, and mocetinostat |
| IIa | HDAC 4, 5, 7, and 9 | Nucleus and cytoplasm |
Tissue-specific | Vorinostat, trichostatin A, belinostat, panobinostat, romidepsin, and ricolinostat (HDAC6 inhibitor) |
| IIb | HDAC 6 and 10 | Cytoplasm | ||
| III | Sirtuins 1–7 | Variable | Variable | Nicotinamide, dihydrocoumarin, and naphthopyranone |
| IV | HDAC 11 | Nucleus and cytoplasm |
Ubiquitous | Vorinostat, trichostatin A, belinostat, and panobinostat |
Abbreviations: HDAC, histone deacetylase.