Table 4.
Subsequent Clinical Outcomes Based on Initial ADHF Occurrence
| Outcome | No ADHF (n=9193) |
ADHF (n=168) |
Hazard Ratio | Lower 95% CI | Higher 95% CI | P value |
|---|---|---|---|---|---|---|
| No. (%) | No (%) | |||||
| Death from any cause - no (%) | 323 (3.5) | 44 (26.2) | 9.5 | 6.7 | 13.1 | <0.001 |
| Death from cardiovascular causes- no (%) | 79 (0.9) | 26 (15.5) | 26.8 | 16.2 | 43.0 | <0.001 |
| Myocardial infarction (MI) -no (%) | 180 (2.0) | 38 (22.6) | 15.7 | 9.9 | 24.0 | <0.001 |
| Non MI acute coronary syndrome - no (%) | 75 (0.8) | 7 (4.2) | 9.9 | 3.7 | 21.6 | <0.001 |
| Stroke - no (%) | 122 (1.3) | 16 (9.5) | 4.0 | 1.4 | 8.8 | 0.003 |
ADHF=acute decompensated heart failure, CI=confidence interval. Data are adjusted for treatment arm, gender, baseline age (in years), baseline chronic kidney disease, and baseline cardiovascular disease.
ADHF was a time-dependent covariate in these models