Fig 3.

A: ¹³C-Specific enrichments of lactate C3 in the S1BF areas at rest or activated of control, MCT2 and UNIV rats (n = 12 10 and 7, respectively). Values represent the % of carbone-13 that was incorporated into the carbon position 3 of lactate from [1-¹³C]glucose infused in the tail vein during the one-hour right whisker stimulation. ¹³C-Specific enrichments of lactate C3 was quantified from the doublet observed on the ¹H-NMR spectra. **: p = 0.003, *: p = 0.016. B: Linear regression between increase in lactate content during brain activation (ratio of lactate content between activated and rest states) and evolution in ¹³C-SE Lact C3 (ratio of ¹³C-SE Lact between activated and rest states, %). Each plot represent on individual rat (blue dot, control rats, r² = 0.795; red squares, MCT2 rats, r² = 0.001 and green triangle, UNIV rats, r² = 0.892).