Table 1.
Pharmacokinetic parameters of KP3 Fc variants following 10 mg/kg IV in mice. ND: not determined because of data fluctuation; Cmax = maximal observed concentration; AUClast = area under the concentration time curve up to the last measurable concentration; AUC∞ = Area under the curve from time zero to infinity; T1/2 = terminal phase elimination half- life; CL = systemic clearance; IV = intravenous injection.
| Test Articles | Cmax (µg/mL) | AUClast (day*µg/mL) | AUCinf (day*µg/mL) | CL (mL/day/kg) | T1/2 (day) |
|---|---|---|---|---|---|
| KP3-IgG | 110.20 | 99.02 | 106.61 | 93.80 | 2.19 |
| KP3-IgG-2Fc-Half | 70.40 | 116.00 | ND | ND | ND |
| KP3-IgG-2Fc-Full | 60.70 | 30.66 | 32.99 | 303.16 | 2.21 |
| KP3-IgG-3Fc | 8.82 | 10.82 | 12.82 | 779.92 | 2.69 |