Table 3.

Correlation coefficient (R), square of correlation coefficient (R²) obtained from a linear regression between experimentally derived value of parameter B and each computationally estimated descriptor. The results from t-tests for the significance of the correlations are also shown and significant correlations are highlighted. ^*

Computationally estimated descriptors	R	R2	Parameter Index	t value	p value
ZVH (Charge on VH region)	−0.49	0.24	x3	2.1032	0.0258
ZVL (Charge on VL region)	−0.48	0.23	x7	2.0473	0.0287
ZmAb (Charge on the antibody)	−0.43	0.18	x2	1.7821	0.0469
ZHinge (Charge on the hinge region)	−0.20	0.04	x5	0.7638	0.2281
ZCH1 (Charge on the CH1 region)	−0.21	0.04	x4	0.8037	0.2167
ZFc (Charge on the Fc region)	0.22	0.05	x6	0.8438	0.2056
ZCL (Charge on the CL region)	0.31	0.10	x8	1.22	0.1201
APTango (Aggregation propensity predicted by TANGO)	−0.21	0.04	x9	0.8037	0.2167
APWaltz (Aggregation propensity predicted by WALTZ)	0.56	0.32	x10	2.5291	0.0112
pISequence (Sequence-based pI)	−0.48	0.23	x11	2.0473	0.0287
pIStructure (Structure-based pI)	−0.41	0.17	x1	1.6819	0.0560
ASAhyd (Hydrophobic surface area)	0.54	0.29	x13	2.4006	0.0144
vdwA (van der Waals surface area)	0.43	0.19	x12	1.7821	0.0469
ASAhlic (Hydrophilic surface area)	0.25	0.06	x14	0.9661	0.1742
DmAb (Dipole moment of the antibody)	−0.50	0.25	x15	2.1602	0.0231
ζmAb (Zeta potential of the antibody)	−0.43	0.18	x16	1.7821	0.0469

^*The straight line fits are shown in Supplemental Material.