Table 4.

Steps followed in this scheme to develop viscosity prediction algorithm. Analogous schemes can be used to develop predict viscosity behaviors of antibodies for different formulations (different buffers, excipients and pH).

Step	Action
I	Collect concentration dependent viscosity curves for different antibodies in the same buffer under the same formulation conditions following the same experimental protocol by performing experiments
II	Build full-length homology models of those antibodies in step I
III	Computationally estimate various descriptors listed in Table 3
IV	Fit the concentration dependent viscosity behavior observed in step 1 to the Eq. 3 to identify the intercept and slope parameters
V	Perform linear regression of the slope parameter (response variable) with the descriptors identified in step IV (predictor variables)