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The HLH-2 proneural protein and the CDK-8 Mediator complex kinase module act with the HLH-3 proneural protein to promote I4 neurogenesis. HLH-2 and CDK-8 most likely act by inhibiting the CYH-1/CDK-7 complex and might also act secondarily by phosphorylating serine 10 of histone H3. CYH-1/CDK-7 might negatively regulate I4 neurogenesis by promoting a myogenic program, whereas H3S10 phosphorylation might facilitate neurogenic gene expression.
