Table 4.
Effect of treatments on oxidative stress markers in brain
| Treatment | Hippocampal markers
|
Frontal cortex markers
|
||||||
|---|---|---|---|---|---|---|---|---|
| Catalase (units/mg of protein) | SOD (units/mg of protein) | GSH (µg/mg of protein) | Total thiols (µg/mg of protein) | Catalase (units/mg of protein) | SOD (units/mg of protein) | GSH (µg/mg of protein) | Total thiols (µg/mg of protein) | |
| Vehicle control | 1.90±0.11 | 12.45±1.04 | 4.77±0.71 | 11.01±0.87 | 2.04±0.11 | 12.94±1.44 | 6.68±0.66 | 12.98±1.01 |
| DOX control | 0.94±0.13* | 7.35±0.54* | 2.11±0.31* | 5.60±0.71* | 1.21±0.12* | 5.44±0.83* | 3.40±0.33* | 6.45±0.89* |
| RUT + DOX | 1.89±0.32# | 12.18±1.04# | 4.52±0.52# | 11.02±1.22# | 1.92±0.12# | 12.08±1.13# | 5.95±0.69# | 12.05±1.46# |
| RUT | 2.01±0.11# | 13.08±1.12# | 4.90±0.42# | 11.31±2.08# | 2.19±0.13# | 13.56±1.10# | 6.55±1.12# | 12.51±1.31# |
Notes: Data represent mean ± SEM of oxidative stress markers in hippocampal and frontal cortex regions in brain;
*
P<0.01 compared to vehicle control,
#
P<0.01 compared to DOX control (n=6).
Abbreviations: DOX, doxorubicin; RUT, rutin; SOD, superoxide dismutase; GSH, glutathione; SEM, standard error of the mean.