Table 6.

Effect of treatments on biochemical parameters

Parameters	Vehicle control	DOX control	RUT + DOX	RUT
AST (U/L)	128.72±8.44	122.53±4.85	116.50±8.26	117.68±8.15
ALT (U/L)	43.60±3.03	45.47±3.19	44.75±3.53	43.98±2.38
ALP (U/L)	103.53±5.80	107.98±7.55	95.44±6.16	98.13±8.29
CK (U/L)	376.05±38.37	801.83±167.91*	398.73±52.92#	421.18±37.80#
Glucose (mg/dL)	73.46±6.92	81.65±2.92	73.67±5.22	80.28±4.20
Urea (mg/dL)	36.66±5.06	96.96±8.87***	41.21±7.82###	33.10±4.32###
Total cholesterol (mg/dL)	55.12±3.18	86.40±3.77***	61.54±2.17###	58.44±3.29###
Triglyceride (mg/dL)	61.98±4.67	147.58±7.53***	79.13±5.46##	49.733±4.41###
Total bilirubin (mg/dL)	0.10±0.00	0.10±0.00	0.08±0.02	0.1±0.02
Creatinine (µmol/L)	31.39±2.17	31.22±1.88	30.06±0.55	30.53±2.01
Total protein (g/dL)	7.02±0.41	7.87±0.17	6.55±0.26	6.43±0.24
Albumin (mg/dL)	4.33±0.30	4.52±0.23	3.98±0.37	4.01±0.15

Notes: Data represent mean ± SEM of various biochemical parameters (n=6).

^*P<0.05,

^***P<0.001 compared to vehicle control;

^#P<0.05,

^##P<0.01,

^###P<0.001 compared to DOX control.

Abbreviations: AST, aspartate transaminase; ALT, alanine transaminase; ALP, alkaline phosphatase; CK, creatinine kinase; DOX, doxorubicin; RUT, rutin; SEM, standard error of the mean.