Table 1. Clinical features of patients with tigecycline- and carbapenem-resistant Klebsiella pneumoniae (TCRKP) infection and molecular types of the TCRKP isolates.
| Patient | Isolate | Hospital | Sex | Age | Underlying Diseases | APACHE Ⅱ Score | Type of Infection | Prior TGC Treatment | Treatment of TCRKP Infection | CarbapenemaseGene | MLST Result | Clinical Outcome | AppropriateAntibioticsTreatment |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P1 | TR1 | A | F | 74 | CVA, Dementia, DM, HTN | 33 | UTI | Yes, Combination therapy for UTI | AN, CL, TGC | ND | 15 | Success | Yes |
| P2 | TR2 | A | M | 88 | COPD, Dementia, DM, HTN | 14 | UTI | No | CL, DOR, GM, LVX | ND | 15 | Success | Yes |
| P3 | TR3 | B | F | 63 | CVA, DM, HTN | 18 | UTI | No | FOF | ND | 15 | Success | Yes |
| P4 | TR4 | C | M | 70 | Hepatoma | 28 | BTI | No | ERT, GM, PTZ | ND | 307 | Death | No |
| P5 | TR5 | D | F | 51 | Lung cancer | 8 | UTI | No | CAZ | ND | 231 | Success | No |
| P6 | TR6 | E | M | 61 | CHF, Esophageal cancer, DM, Uremia | 24 | Pneumonia | No | CL, MEM | ND | 1192 | Death | Yes |
| P7 | TR7 | F | M | 85 | DM, Prostate cancer | 37 | UTI | No | TGC | blaIMP-8 | 1087 | Success | No |
| P8 | TR8 | G | M | 72 | CVA, Cholangiocarcinoma | 15 | BTI | Yes, Combination therapy for BTI | CL, ERT, FEP | ND | 307 | Success | Yes |
| P9 | TR9 | A | F | 34 | Liver cirrhosis | 14 | UTI | Yes, Combination therapy for UTI | CL | ND | 1619 | Success | No |
| P10 | TR10 | E | M | 81 | CVA, COPD, DM, Prostate cancer | 24 | UTI | Yes, Monotherapy for UTI | TGC | blaKPC-2 | 11 | Death | No |
| P11 | TR11 | A | F | 32 | Dilated cardiomyopathy, DM | 26 | UTI | No | FEP, TGC | ND | 15 | Death | No |
| P12 | TR12 | G | M | 3 | Acute lymphoblastic leukemia | 15 | Bacteremia | No | AN, MEM, SXT | ND | 711 | Death | Yes |
| P13 | TR13 | D | M | 83 | DM, Uremia | 33 | UTI | No | AN, ETP, PTZ | ND | 11 | Success | Yes |
| P14 | TR14 | H | F | 45 | Bipolar disorder | 22 | UTI | No | CL, FEP | ND | 1644 | Success | Yes |
| P15 | TR15 | D | M | 88 | CAD, DM | 37 | Pneumonia | No | FEP | ND | 1253 | Death | Yes |
| P16 | TR16 | C | F | 103 | DM | 16 | Peritonitis | No | CL, TGC | blaIMP-8 | 1565 | Death | Yes |
AN, amikacin; APACHE II, Acute Physiology and Chronic Health Evaluation II; BTI, biliary tract infection; CAD, coronary artery disease; CAZ, ceftazidime; CHF, congestive heart failure; CL, colistin; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular accident; DM, diabetes mellitus; DOR, doripenem; ERT, ertapenem; F, female; FEP, cefepime; FOF, fosfomycin; GM, gentamicin; HTN, hypertension; LVX, levofloxacin; M, male; MEM, meropenem; MLST, multilocus sequence typing; ND, not detected; PTZ, piperacillin/tazobactam; SXT, trimethoprim-sulfamethoxazole; TCRKP, tigecycline- and carbapenem-resistant Klebsiella pneumoniae; TGC, tigecycline; UTI, urinary tract infection.