Table 1. Demographic data of the study participants.
| SIVD | AD | NC | ANOVA | ||
|---|---|---|---|---|---|
| (n = 35) | (n = 40) | (n = 33) | F | p | |
| Age | 73.3 (11.3) | 72.2 (8.6) | 69.9 (12.2) | 0.905 | 0.408 |
| Education | 6.8 (4.2) | 5.7 (4.0) | 7.3 (4.6) | 1.430 | 0.244 |
| Disease duration (year) | 1.2 (0.7) | 1.0 (0.6) | 0.0 (0.0) | 48.279 | < 0.001AB |
| Hachinski score | 7.1 (3.0) | 1.1 (0.9) | 0.6 (0.7) | 136.952 | <0.001 AC |
| Fazekas scale (Total) | 4.7 (1.0) | 2.1 (1.2) | 1.8 (1.1) | 73.535 | <0.001 AC |
| Periventricular white matter | 2.3 (0.6) | 1.1 (0.6) | 1.0 (0.6) | 52.423 | < 0.001 AC |
| Deep white matter | 2.3 (0.6) | 1.0 (0.9) | 0.8 (0.8) | 42.516 | < 0.001 AC |
| Chi-Square tests | |||||
| X2 | p | ||||
| Gender (M/F) | 27/8 | 20/20 | 16/17 | 5.878–6.000 | 0.015–0.014ac |
| Systemic diseases (n) | |||||
| Cerebrovascular disease | 12 | 3 | - | 8.371 | 0.004C |
| Hypertension | 17 | 12 | - | 2.715 | 0.099 |
| Diabetes mellitus | 12 | 7 | - | 2.781 | 0.095 |
| Chronic kidney disease | 7 | 7 | - | 0.077 | 0.782 |
| Medications (n) | |||||
| Antipsychotics | 0 | 1 | - | 0.887 | 0.346 |
| Anxiolytics | 0 | 7 | - | 6.756 | 0.009C |
| Antidepressants | 4 | 5 | - | 0.020 | 0.887 |
A:p<0.001 on comparison between SIVD and the control;
a:p<0.05 on comparison between SIVD and the control;
B:p <0.001 on comparison between AD and the control;
C:p<0.001 on comparison between SIVD and AD;
C:p<0.01 on comparison between SIVD and AD;
c:p<0.05 on comparison between SIVD and AD.
Data presented as Mean (Standard deviation) unless stated elsewhere. AD: Alzheimer’s disease; SIVD: Subcortical ischemic vascular disease; NC: Normal Control; ANOVA: Analysis of variance.