Table 1. Frequency of epimutants/mutants in the wild type, sexM and RNAi mutant strains.
| Strain | Background | Total analyzed | Mutations in fkbA | Mutations in cnaA/cnbR | No mutation found | Epimutants # | Epimutants % | p-value* |
|---|---|---|---|---|---|---|---|---|
| NRRL3631 | Wild type | 33 | 22 | 0 | 11 | 10 | 30.3 | |
| R7B | leuA- | 31 | 22 | 1 | 8 | 7 | 22.6 | |
| MU412 | r3b2Δ::pyrG leuA- | 33 | 3 | 0 | 30 | 28 | 84.9 | 8x10-7 |
| MU429 | r3b2Δ::pyrG leuA- | 28 | 7 | 1 | 20 | 20 | 71.4 | 0.0002 |
| MU430 | qipΔ::pyrG leuA- | 23 | 18 | 3 | 2 | 0 | <4.3 | 0.034 |
| MU437 | rnhAΔ::pyrG leuA- | 30 | 27 | 1 | 2 | 0 | <3.3 | 0.011 |
| MU500 | rdrp3Δ::pyrG leuA- | 30 | 4 | 0 | 26 | 26 | 86.7 | 5x10-7 |
| MU439 | rdrp3Δ::pyrG leuA- | 19 | 3 | 0 | 16 | 16 | 84.2 | 0.00003 |
| MU440 | rdrp3Δ::pyrG leuA- | 15 | 0 | 0 | 15 | 15 | 100.0 | 3x10-7 |
| MU423 | sexMΔ::pyrG leuA- | 15 | 12 | 0 | 3 | 3 | 20.0 | 1 |
| MU424 | sexMΔ::pyrG leuA- | 16 | 13 | 0 | 3 | 3 | 18.8 | 1 |
*p-values were obtained based on a Fisher Exact Probability Test for a 2x2 Contingency Table, comparing each of the mutant strains individually versus the R7B strain.