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Assessment of GA using FAF. In a healthy retina, lipofuscin autofluorescence is distributed uniformly in a pattern that diminishes toward the fovea. In contrast, distinct dark areas are evident in the eye with GA, where death of lipofuscin-containing RPE cells leaves a region of hypofluorescence. Different FAF patterns in the junctional zone have been correlated with varying risk of GA progression.55 IQR, interquartile ratio.
