Fig. 3A–C.

Tissue sections with (A) wear debris contained (B) CD68+ macrophages (n = 30). The blue arrows indicate wear particles (polarized light image) and the red arrows macrophages. The graph (C) shows the amount of UHMWPE wear debris strongly correlated with the number of CD68+ macrophages. Data are presented as median ± SD. The circles and stars represent the outliers and extremes, respectively. Sections were immunostained using DAB as the chromogenic substrate and counterstained with 50% hematoxylin; the scale bar is 50 μm.