Table 4.

Study characteristics of bone scintigraphy for detection of periprosthetic knee infection

Study	Tracer	Doses	Criteria for infection
Palestro et al. [34]	99mTc-MDP	740 MBq	When hyperperfusion and hyperemia around at least one component of the prosthesis were present on dynamic and blood pool images and periprosthetic activity of at least Grade 2 around the same component was present on delayed images
Nijhof et al. [27]	99mTc-MDP	600 MBq	When there was increased activity in at least two phases (blood pool and late phase) in the area of interest
van Acker et al. [50]	99mTc-MDP	740 MBq	Any periprosthetic focal uptake in the delayed phase
Larikka et al. [20]	99mTc-HDP	550 MBq	Uptake in the arterial/flow phase
Rubello et al. [40]	99mTc-MDP	NR	Uptake in the arterial/flow phase
Granados et al. [12]	99mTc-HDP	925 MBq	Uptake in the arterial/flow phase

Diagnostic odds ratio 8.956; heterogeneity chi-square = 8,09 (df = 5) p = 0.151; Inconsistency (I²) = 38,2%; 99 mTc = 99m-technetium; MDP = methylenediphosphonate; HDP = hydroxymethylenediphosphonate.