Table 1.
Baseline characteristics of the study population
| Variable | Overall (n = 443) | No recurrence (n = 344) | Recurrence (n = 99) | p value* |
|---|---|---|---|---|
| Age at entry (years) | 62 (47–74) | 61 (46–73) | 68 (56–75) | 0.026 |
| Female gender | 217 (49%) | 170 (49%) | 47 (48%) | 0.733 |
| Nonextremity location | 84 (19%) | 63 (18%) | 21 (21%) | 0.517 |
| Deep tumor | 284 (64%) | 215 (63%) | 69 (70%) | 0.188 |
| Tumor size > 5 cm | 310 (70%) | 231 (67%) | 79 (80%) | 0.016 |
| Histology | 0.02 | |||
| Liposarcoma | 113 (26%) | 100 (29%) | 13 (13%) | NA |
| Myxofibrosarcoma | 131 (30%) | 98 (29%) | 33 (33%) | NA |
| Leiomyosarcoma | 44 (10%) | 30 (9%) | 14 (14%) | NA |
| Other | 109 (25%) | 80 (23%) | 29 (29%) | NA |
| Synovial sarcoma | 31 (7%) | 26 (8%) | 5 (5%) | NA |
| MPNST | 15 (3%) | 10 (3%) | 5 (5%) | NA |
| Resection margins | 0.656 | |||
| Wide | 399 (90%) | 311 (90%) | 88 (89%) | NA |
| Marginal | 44 (10%) | 33 (10%) | 11 (11%) | NA |
| Intralesional | 0 (0%) | 0 (0%) | 0 (0%) | NA |
| Tumor grade | 0.001 | |||
| 1 | 97 (22%) | 89 (26%) | 8 (8%) | NA |
| 2 | 82 (19%) | 61 (18%) | 21 (21%) | NA |
| 3 | 264 (60%) | 194 (56%) | 70 (71%) | NA |
| AJCC stage | < 0.001 | |||
| I | 98 (22%) | 89 (26%) | 9 (9%) | NA |
| II | 175 (40%) | 140 (41%) | 35 (35%) | NA |
| III | 170 (38%) | 115 (33%) | 55 (56%) | NA |
| Adjuvant chemotherapy | 40 (9%) | 26 (8%) | 14 (14%) | 0.041 |
| Adjuvant radiotherapy | 260 (59%) | 200 (58%) | 60 (61%) | 0.661 |
Distribution overall and by total recurrence status; continuous variables are summarized as medians [25th percentile (Q1) to 75th percentile (Q3)], whereas categorical variables are reported as absolute frequencies and percentages; *p values for difference between nonrecurrence and recurrence group are from Pearson’s chi-square tests (categorical variables with expected cell counts ≥ 5), Fisher’s exact tests (categorical variables with expected cell counts < 5), or Wilcoxon rank-sum tests (continuous variables); MPNST = malignant peripheral nerve sheath tumor; AJCC = American Joint Committee on Cancer; NA = not applicable.