Table 1.
Patients’ characteristics
| Variables | All patients N = 186 (100%) |
Follow up ≥ day 14 and no AKI day 2–14 N = 87 (47%) |
Follow up ≥ day 14 and AKI day 2–14 N = 85 (46%) |
P valuea |
|---|---|---|---|---|
| N (%) | ||||
| Male | 91 (49%) | 36 (41%) | 47 (55%) | 0.07 |
| Death day 1–14 | 11 (6%) | 0 (0%) | 0 (0%) | –b |
| Death day 1–1 year | 29 (16%) | 1 (1%) | 17 (20%) | < 0.001 |
| Reason transplantation | – | – | – | 0.03 |
| CF | 57 (31%) | 17 (20%) | 33 (39%) | 0.005 |
| COPD, emphysema, alpha-1-antitrypsin deficiency | 80 (43%) | 48 (55%) | 28 (33%) | 0.003 |
| Sarcoidosis/ILD/UIP | 14 (8%) | 7 (8%) | 6 (7%) | 0.81 |
| Others: PAH, IPF, bronchiectasis, allergic alveolitis, LCH, LAM | 35 (19%) | 15 (17%) | 18 (21%) | 0.51 |
| Double transplantation | 148 (80%) | 64 (74%) | 73 (86%) | 0.045 |
| Diabetes mellitus | 40 (22%) | 13 (15%) | 21 (25%) | 0.11 |
| Preoperative ECMO | 1 (0.5%) | 1 (1%) | 0 (0%) | 1.00 |
| Perioperative ECMO | 118 (63%) | 45 (52%) | 62 (73%) | 0.004 |
| ICU admission before | 19 (10%) | 7 (8%) | 11 (13%) | 0.29 |
| Complications | 91 (49%) | 35 (40%) | 45 (53%) | 0.10 |
| Reoperation due to bleeding | 43 (23%) | 13 (15%) | 20 (24%) | 0.15 |
| Infection | 48 (26%) | 15 (17%) | 33 (39%) | 0.002 |
| Rejection | 22 (12%) | 7 (8%) | 14 (17%) | 0.09 |
| Other | 27 (15%) | 9 (10%) | 17 (20%) | 0.08 |
| At least once during day 1–6 | ||||
| Liver injury | 53 (29%) | 17 (20%) | 31 (37%) | 0.013 |
| Anemia | 182 (98%) | 85 (98%) | 85 (100%) | 0.50 |
| Low protein concentration | 129 (69%) | 58 (67%) | 65 (77%) | 0.15 |
| Supra-therapeutic whole-blood tacrolimus trough concentration | 135 (73%) | 61 (70%) | 71 (84%) | 0.04 |
| SIRS | 172 (93%) | 81 (93%) | 81 (95%) | 0.7 |
| Shock | 115 (62%) | 47 (54%) | 61 (72%) | 0.016 |
| At least one drug increasing tacrolimus concentration | 181 (97%) | 85 (98%) | 85 (100%) | 0.50 |
| At least one drug decreasing tacrolimus concentration | 157 (84%) | 71 (82%) | 78 (92%) | 0.05 |
| Nephrotoxic drugs other than tacrolimus | 178 (96%) | 85 (98%) | 83 (98%) | 1.0 |
| Mean (SD) | P value a | |||
| Age (year) | 46 (13.3) | 47 (12.8) | 45 (13.9) | 0.2 |
| BMI | 22 (3.7) | 23 (3.6) | 22 (3.8) | 0.8 |
aChi-square test, Fisher’s exact test, or t test where appropriate
bNo statistics are computed because no death occurred