Skip to main content
. 2017 Jan 28;73(5):573–580. doi: 10.1007/s00228-017-2204-8

Table 2.

Linear mixed model to test the variables influencing whole-blood tacrolimus trough concentrations

Fixed effect Estimateab 95% CI
• CF −0.16 −0.28 −0.03
• Liver injury 0.04 −0.08 0.16
• Drugs increasing tacrolimus −0.02 −0.09 0.05
• ≥2 drugs increasing tacrolimus −0.13 −0.25 0.00
• 1 or 2 drugs decreasing tacrolimus −0.06 −0.13 0.01
• Day 1.24 1.02 1.46
• Day squaredc −0.13 −0.15 −0.10

aEstimate = regression coefficient in a linear mixed model, with log (tacrolimus concentration) as outcome variable

bEstimate of intercept = −0.19

cA quadratic term is included in the model because there was no linear relationship between outcome variable and factors included in the model