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. 2016 Oct 28;46(4):301–308. doi: 10.1007/s00249-016-1182-6

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — a Thermodynamic signatures of a variety of Immucillins binding to the first subunit of human PNP at 300 K: ΔG (blue), ΔH (red), and −TΔS (green), exhibiting EEC compensation. b Plot of the data showing that as the enthalpy, ΔH, becomes more positive by about 60 kJ/mol, the entropy factor −TΔS compensates by becoming more negative by about 45 kJ/mol. From Edwards et al. (2009)