Table 3.

Independent factors associated with death before day 8 or before day 30 in all adult patients with incident episode of fungemia due to single isolate of common Candida species (YEATS program, Paris area, 2002–2014)

	Death before day 8a				Death before day 30b
	ORc	95% CI		p	ORc	95% CI		p
Age category (years)
<45	1				1
45–64	1.39	0.94–2.05	0.101	0.0073	1.59	1.20–2.09	0.001
65–79	1.76	1.18–2.62	0.005		2.13	1.60–2.84	<0.0001	<0.0001
≥80	2.11	1.30–3.41	0.002		2.92	2.05–4.15	<0.0001
Hospitalization in ICU	2.39	1.84–3.12	<0.0001		2.47	2.03–3.01	<0.0001
Recent surgery (≤30 days)	0.75	0.57–0.97	0.031		0.66	0.54–0.80	<0.0001
Underlying disease
No malignancy					1
Digestive tumor					1.42	1.08–1.85	0.012
Non-digestive tumor					1.42	1.10–1.84	0.007	0.00487
Acute leukemia					1.06	0.70–1.62	0.773
Lymphoma					1.25	0.88–1.78	0.214
Other hematological malignancy					0.99	0.64–1.56	0.982
Species recovered from blood culture
C. albicans	1				1
C. glabrata	0.61	0.43–0.89	0.009		0.69	0.54–0.89	0.004
C. parapsilosis	0.30	0.17–0.52	<0.0001	<0.0001	0.49	0.35–0.67	<0.0001	<0.0001
C. tropicalis	1.00	0.67–1.49	0.999		1.00	0.74–1.34	0.987
C. krusei	1.24	0.62–2.44	0.544		1.52	0.91–2.54	0.106
C. kefyr	1.79	0.84–3.80	0.132		1.36	0.74–2.53	0.325
Initial antifungal treatment
Fluconazole alone	1				1
Echinocandin alone	1.02	0.74–1.41	0.909	<0.0001	1.08	0.86–1.36	0.517	<0.0001
Other treatments	0.75	0.46–1.21	0.234		0.84	0.62–1.15	0.283
No antifungal drug	10.96	7.60–15.81	<0.0001		4.94	3.51–6.95	<0.0001

^aOther variables included in full model (with p < 0.25 in univariate analysis of early death) not conserved because not significant: allo-BMT, male gender, and type of underlying disease

^bMale gender included in the model but not conserved because not significant

^cOR adjusted for hospital and year (introduced in the model as dummy variable)